Vomiting is a complex reflex activity. Various antiemetic drugs can exert antiemetic effects by affecting different links of the vomiting reflex, such as inhibiting chemoreceptors, cerebral cortex, ear vestibular apparatus, or directly acting on the vomiting center. These compounds are widely used for motion sickness, radiation sickness, or vomiting caused by chemotherapy clinically. Commonly used antiemetic APIs include dopamine and serotonin antagonists, neurokinin-1 receptor antagonists, antihistamines, and anticholinergics.

Emetics are mainly used to vomit poisonous substances in the stomach. Its emetic effect mainly induces vomiting chemoreceptors through the excitement center, such as apomorphine, or stimulates the digestive tract reflex to excite the vomiting center. At present, gastric lavage is often used to replace vomiting drugs.

Protheragen offers a full range of antiemetic & emetic APIs to support the research of customers worldwide.