Solid microneedles, as an emerging micro and nanotechnology, have shown great potential in various fields. Protheragen specializes in the design, development, and production of cutting-edge solid microneedles. We are committed to providing high-quality solid microneedle development services to our customers to help them realize innovative breakthroughs in the fields of medicine, aesthetics, and bioscience.

Background

Solid microneedles are elongated structures with micrometer dimensions, usually made of typically metal, silicon, or polymers. They can vary in diameter from tens to hundreds of micrometers and have a sharp tip. This type of microneedle structure is designed to penetrate the stratum corneum to enhance drug delivery to the dermis, thereby improving bioavailability and kinetic transport across the skin.

Solid microneedles are suitable for vaccine delivery because they last longer and have a more robust antibody response. Solid microneedles are easy to manufacture and have excellent mechanical properties and sharper tips.

Fig. 1 Solid microneedles made of (a~d) silicon, (e~h) metals and (i~l) polymer. (Aldawood FK, et al. 2021)

Preparation Methods of Solid Microneedles

Protheragen utilizes advanced manufacturing techniques to prepare solid microneedles with superior precision and reliability. Each method has its unique advantages and scope of application. We have the experience and expertise to select the most appropriate preparation method for our customer's needs and to ensure that the quality and performance of solid microneedles meet expectations.

• Laser ablation.
• Mmicro-molding.
• Additive manufacturing.
• Injection molding.
• Chemical isotropic etching.
• Surface/bulk micromachining.
• Lithography-electroforming-replication.

Our Services

We offer a full range of services related to solid microneedle development. Our capabilities include:

• Design and Customization - Depending on your needs and application scenarios, we can develop custom microneedle designs. We consider factors such as needle length, diameter, density, and surface modification to ensure optimal performance in your intended application.
• Prototyping and Manufacturing - We can rapidly prototype and manufacture solid microneedles to validate the design and evaluate its performance. We use precise manufacturing techniques to ensure consistent and repeatable results.
• Material Selection - We guide selecting the right biocompatible materials for microneedle manufacturing, taking into account factors such as biocompatibility, mechanical strength, and compatibility with drug formulations or sensing applications.
• Functionalization and Surface Modification - We focus on surface modification techniques to enhance microneedle performance. This includes surface coatings, functionalization of biomolecules, or incorporation of drug-carrying particles for controlled release.
• Characterization and Testing - We use advanced analytical techniques to evaluate mechanical strength, needle sharpness, drug loading and release kinetics, and biocompatibility to ensure that microneedles meet the required specifications.
• Scale-up and Manufacturing - We can assist with the transition from the prototyping stage to large-scale manufacturing, ensuring seamless integration into your production workflow.
• Technical Consulting and Support - We provide technical consulting and support to our customers to help them address issues and challenges in the development of solid microneedles.

Advantages of Our Solid Microneedles

Through our R&D and production, our solid microneedles have the following advantages:

• High-quality materials.
• Accurate preparation.
• Efficient drug delivery.
• Minimally Invasive
• Flexibility and Customizability.

If you are interested in solid microneedle development services or have any questions, please feel free to contact us. Our team will be happy to provide you with professional support and solutions to help you succeed in the field of solid microneedles.