Pretheragen offers a wide range of high-purity phosphoramidite series products. These molecules serve as the foundation for constructing DNA, RNA, and various modified oligonucleotides, driving innovation in multiple cutting-edge fields. From basic academic research to the commercial production of therapeutic oligonucleotide drugs, our phosphoramidite products provide core chemical tools for global research institutions and pharmaceutical companies in areas such as gene editing and molecular diagnosis.

Product Category

Our comprehensive portfolio of phosphoramidites spans all monomer types, from standard to highly specialized.

• Standard nucleoside phosphoramidates

We offer basic building blocks including dA, dC, dG, and dT, with DMT protecting groups and various base protecting groups, which is a reliable choice for synthesizing natural DNA sequences.

• Monomer units for RNA synthesis

We provide 2'-O-TBDMS and 2'-O-MOE protected ribonucleoside phosphoramidates to ensure efficient and high-yield synthesis of biologically active RNA molecules.

• Chemically modified monomers

We offer a wide variety of modified monomers to enhance the stability and functionality of oligonucleotides, such as 2'-position modification, locked nucleic acid (LNA), Bridged Nucleic Acid (BNA), etc.

• Special function monomers

We provide double-stranded monomers, as well as universal bases and rare bases, which significantly shorten the synthesis cycle, increasing yield and flexibility.

Application

Therapeutic oligonucleotides: As the core raw material for innovative drugs such as synthetic small interference RNA (siRNA), antisense oligonucleotides (ASO), aptamers, etc.

Molecular diagnostics: Used for probing in the synthesis of gene detection chips, PCR primers, sequencing primers, and molecular beacons.

Synthetic biology: Used for gene synthesis and the preparation of gene editing tools.

Basic scientific research: Supporting daily experiments in basic life science research such as genomics, drug target discovery and validation.

Our Advantages

• We offer a full range of phosphoramidite products in various specifications and levels, accelerating the process from research to drug development.
• Our extensive library of modified monomers helps our customers develop the next generation of drugs with higher activity, better stability and greater safety.
• Our team is well-versed in oligonucleotide chemistry and technology, providing customers with professional product selection, application consultation and customized synthesis services, jointly addressing technical challenges.

We possess an industry-leading R&D platform and large-scale production capacity, and are always committed to providing our customers with cutting-edge and reliable phosphoramidite series solutions. If you cannot find the product you need in our catalog or require more detailed information, please contact us. We will get back to you within 2-4 working days.