Carbon exists in various forms in the atmosphere, the earth's crust and living bodies, and is known as the element of life. Protheragen provides industry-leading carbon-labeled products, including 13C/14C-Labeled Kits, 14C-Intermediates, 14C-Sugars, 14C-Amino Acids, and 14C-Lipids and Steroids.

Technical Advantages of 13C/14C Labeling

• Universal presence

Carbon-based life forms are a universal characteristic of earth's organisms, and all known life forms are composed of carbon as their basic building block.

• Weak isotope effect

13C/14C labeling has small impact on the chemical properties of the original molecule, enabling it to effectively reflect the metabolic pathways and distribution characteristics of compounds in real human bodies and environments.

• High labeling stability  

The 13C/14C labeling sites are typically located on the backbone of the molecular structure, ensuring that the labeled compounds remain highly stable during experiments and are unlikely to detach.

• Reliable experimental results  

13C/14C tracing analysis technology is unaffected by matrix effects, has extremely low background noise, and yields more reliable results compared to control experiment methods.

Applications of 13C/14C Labeling

13C/14C labeling technology is a high-precision research method based on radioactive isotope tracing, with a wide range of applications.

• Labeling and tracing

13C/14C labeling is used to study the distribution of substances, elucidate migration processes, analyze trace substances, and measure biological activity. For example, it is used to study the residual, migration, and degradation pathways of pesticides in the environment, thereby reducing the risk of pesticide abuse.

• Drug research

13C/14C labeling quantitatively studies the absorption, distribution, metabolism, and excretion patterns of drugs within the organism and reflects changes in blood drug concentrations over time.

• Disease diagnosis

13C/14C labeling is widely used for clinical disease diagnosis, offering the advantages of simplicity, speed, sensitivity and non-invasiveness. Patients first receive a quantitative dose of 13C/14C-labeled drugs. After absorption and metabolism by specific tissues or regions in the body, labeled drugs produce labeled CO2 gas, which is exhaled. By collecting and detecting the concentration of this gas, the condition of specific body regions can be diagnosed.

Protheragen offers the following products based on 13C and 14C, covering the entire demand chain from basic research to industrial applications. If you are interested in our Carbon-Labeled Products, please contact us.

• 13C/14C-Labeled Kits
• 14C-Amino Acids
• 14C-Intermediates
• 14C-Lipids and Steroids
• 14C-Sugars