Helicobacter pylori (Hp), a Gram-negative bacterium, is the first type of carcinogenic factor for gastric cancer. Accurate diagnosis of Hp infection is a crucial step in the prevention and treatment of digestive tract diseases and holds significant clinical value.

The Detection Methods for Hp

The currently commonly used clinical methods for detecting Hp can be divided into invasive and non-invasive types.

Invasive Methods

Invasive methods mainly rely on an endoscopic examination, which is suitable for the diagnosis of Hp-related diseases such as peptic ulcers, atrophic gastritis, lymphoma, etc.

Non-invasive Methods

• Urea breath test
• Serological testing
• Fecal antigen test

Among them, the urea breath test has become the preferred diagnostic method and therapeutic efficacy assessment tool in clinical practice due to its high accuracy, simple operation and lack of pain.

Principle of the Urea Breath Test

Urease is absent in mammalian cells, but the Hp in the stomach secretes highly active urease. When oral C13 or C14-labeled urea capsules are ingested and enter the stomach, the urease in the stomach can decompose the urea in the capsules into ammonia and C13 or C14-labeled CO2. The CO2 is absorbed into the blood and enters the lungs along with the blood flow, then exhaled in the form of gas. By detecting whether the exhaled gas contains the labeled C13 or C14, it is able to determine whether there is Hp infection, and the degree of infection can be judged based on the detected content.

Our Products

C14 is a weakly radioactive isotope, with fast detection speed and high sensitivity; C13 is a stable nuclide without radioactivity. As a leading supplier of Hp detection products, Protheragen offers professional C13 and C14 labeled urea breath test solutions.

Applicable Scenarios of the C13 Urea Breath Test

• Pediatric patients
• Pregnant and lactating women
• Cases requiring repeated tests
• Scientific research

Applicable Scenarios of the C14 Urea Breath Test

• Routine adult testing
• Primary medical institutions
• Large-scale screening
• Post-treatment re-examination

We strictly follow international standards to produce labeled urea reagents. Whether you are looking for a safe C13 solution or a cost-effective C14 solution, we can provide professional and reliable testing products. If you need more details, please contact us.