Benzquinamide Hydrochloride

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Cat Number

API113699

CAS Number

113-69-9

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CAS Number

113-69-9

EINECS

204-033-3

Synonyms

3-carbamoyl-N,N-diethyl-1,3,4,6,7,11b-hexahydro-9,11-dimethoxy-2H-benzo[a]quinolizin-2-yl acetate hydrochloride

Molecular Formula

C22H33ClN2O5

Molecular Weight

441

Smiles

CCN(CC)C(=O)C1CN2CCC3=CC(=C(C=C3C2CC1OC(=O)C)OC)OC.Cl

Appearance

Off-white to light yellow solid

Melting Point

229-231℃

General Description

Benzquinamide Hydrochloride is a benzoquinoline derivative classified as an antiemetic with combined dopamine D2 receptor antagonist and antihistamine properties.

Mechanism of Action

Benzquinamide blocks dopamine D2 receptors in the chemoreceptor trigger zone of the medulla, inhibiting the emetic reflex. It also exhibits H1 receptor antagonism contributing to its antiemetic and sedative effects.

Application

Used in the prevention and treatment of nausea and vomiting. Benzquinamide Hydrochloride is indicated for postoperative nausea and vomiting, chemotherapy-induced emesis, and radiation sickness.

What distinguishes Benzquinamide from other dopamine D2 antagonist antiemetics?

Benzquinamide combines D2 antagonism with H1 receptor blockade, providing dual antiemetic mechanisms that may benefit patients resistant to single-mechanism antiemetics.