Sibutramine Hydrochloride

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Cat Number

API84485007

CAS Number

84485-00-7

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Product Detail Description Customer Q&A

CAS Number

84485-00-7

Molecular Formula

C17H27Cl2N

Molecular Weight

316.3

Smiles

CC(C)CC(C1(CCC1)C2=CC=C(C=C2)Cl)N(C)C.Cl

Appearance

White solid

General Description

Sibutramine Hydrochloride is a cyclobutylamine derivative classified as a centrally acting appetite suppressant. It acts as a serotonin and norepinephrine reuptake inhibitor with additional dopaminergic activity.

Mechanism of Action

Sibutramine inhibits presynaptic reuptake of serotonin and norepinephrine, increasing their concentrations in synaptic clefts within appetite-regulating centers of the hypothalamus, promoting satiety and reducing food intake.

Application

Used in the management of obesity. Sibutramine Hydrochloride is indicated for weight management in patients with a body mass index of 30 or higher, or 27 or higher with comorbidities such as hypertension or diabetes.

What dual mechanism makes Sibutramine effective for weight loss?

Sibutramine enhances both serotonin-mediated satiety signaling and norepinephrine-mediated thermogenesis, providing combined appetite suppression and energy expenditure enhancement.