Sulfoxone

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Cat Number

API120627

CAS Number

120-62-7

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Product Detail Description Customer Q&A

CAS Number

120-62-7

EINECS

204-412-3

Storage

2-8℃

Molecular Formula

C18H28O3S

Molecular Weight

324.48

Smiles

CCCCCCCCS(=O)C(C)CC1=CC2=C(C=C1)OCO2

Boiling Point

432.8℃

Relative Density

1.1

General Description

Sulfoxone (diaminodiphenylsulfone sodium methanesulfonate) is the sodium methanesulfonate salt of sulfoxone, which is itself the methanesulfonylmethyl derivative of dapsone (4,4'-diaminodiphenylsulfone). It is a water-soluble prodrug precursor to dapsone with antimycobacterial and anti-inflammatory activity.

Mechanism of Action

Sulfoxone is hydrolyzed in vivo to dapsone, which inhibits dihydropteroate synthase in susceptible bacteria by competing with para-aminobenzoic acid (PABA), disrupting folate biosynthesis. Dapsone also exerts anti-inflammatory effects through inhibition of myeloperoxidase and neutrophil function.

Application

Indicated for the treatment of leprosy and dermatitis herpetiformis. Sulfoxone is a water-soluble prodrug of dapsone with antimycobacterial and anti-inflammatory activity, hydrolyzed in vivo to dapsone which inhibits folate biosynthesis and suppresses neutrophil-mediated inflammation.

How does Sulfoxone relate to dapsone in therapy?

Sulfoxone is a water-soluble prodrug hydrolyzed to dapsone in vivo, providing improved oral bioavailability and a different pharmacokinetic profile for patients requiring dapsone therapy.