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Umbralisib tosylate

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Cat Number

API1532533724

CAS Number

1532533-72-4

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Product Detail

CAS Number

1532533-72-4

Synonyms

RP5264 tosylate,TGR-1202 tosylate ; RP5264 tosylate,TGR-1202 tosylate

Description

Umbralisib Tosylate (TGR-1202) is a potent, selectively dual inhibitor targeting PI3Kδ and casein kinase-1-ε (CK1ε), demonstrating oral activity. With EC50 values of 22.2 nM and 6.0 μM for PI3Kδ and CK1ε respectively, it shows unique immunomodulatory effects on T cells in chronic lymphocytic leukemia (CLL). This compound is utilized in the research of hematological malignancies.

Molecular Formula

C38H32F3N5O6S

Molecular Weight

743.75

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