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Umbralisib tosylate

Umbralisib tosylate

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Cat Number
API1532533724
CAS Number
1532533-72-4

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CAS Number
1532533-72-4
Synonyms
RP5264 tosylate,TGR-1202 tosylate ; RP5264 tosylate,TGR-1202 tosylate
Description
Umbralisib Tosylate (TGR-1202) is a potent, selectively dual inhibitor targeting PI3Kδ and casein kinase-1-ε (CK1ε), demonstrating oral activity. With EC50 values of 22.2 nM and 6.0 μM for PI3Kδ and CK1ε respectively, it shows unique immunomodulatory effects on T cells in chronic lymphocytic leukemia (CLL). This compound is utilized in the research of hematological malignancies.
Molecular Formula
C38H32F3N5O6S
Molecular Weight
743.75
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