LX1

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Cat Number

API2647877845

CAS Number

2647877-84-5

For research use only. We do not supply to patients.

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Product Detail

CAS Number

2647877-84-5

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Description

LX1, an anti-prostate cancer compound, specifically targets the androgen receptor (AR), AR variants, and the steroidogenic enzyme AKR1C3. It inhibits AKR1C3's enzymatic function, decreases the conversion of androstenedione to testosterone, and reduces the expression of both AR and AR-V7, subsequently downregulating their target genes. Additionally, LX1 is effective in overcoming tumor cell resistance to Enzalutamide, and when combined with Enzalutamide, it further suppresses tumor growth.

Molecular Formula

C22H15F6NO2

Molecular Weight

439.35

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