Desvenlafaxine

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Cat Number

API0231576

CAS Number

93413-62-8

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Product Detail Description Scientific Support Customer Q&A

CAS Number

93413-62-8

EINECS

700-516-2

Storage

Store at room temperature

Synonyms

O-Desmethylvenlafaxine; 4-(2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenol; Khedezla; Newven; Desvenlafaxina; NG99554ANW

Molecular Formula

C16H25NO2

Molecular Weight

263.37

Smiles

CN(C)CC(C1=CC=C(C=C1)O)C2(CCCCC2)O

Appearance

White to off-white powder

Melting Point

208-213℃

Boiling Point

403.8℃ at 760 mmHg

Relative Density

1.115

General Description

Desvenlafaxine is the principal active metabolite of venlafaxine and functions as a serotonin-norepinephrine reuptake inhibitor (SNRI). The drug exhibits a linear pharmacokinetic profile and a relatively short half-life, yet maintains steady-state concentrations with once-daily administration.

Mechanism of Action

Desvenlafaxine potently inhibits the presynaptic reuptake of both serotonin and norepinephrine, increasing their availability in central synaptic clefts. It has negligible affinity for muscarinic, histaminergic, or adrenergic receptors, which accounts for its favorable side effect profile relative to older antidepressants. The dual monoamine elevation is thought to enhance mood, energy, and concentration by modulating circuits involved in emotion regulation.

Application

Approved primarily for major depressive disorder in adults, desvenlafaxine has demonstrated efficacy in reducing both emotional and physical symptoms of depression. It is also used off-label for vasomotor symptoms associated with menopause, such as hot flashes, where non-hormonal options are preferred.

Many patients with depression have comorbid chronic physical conditions, leading to complex polypharmacy and increased risk of drug‑drug interactions (DDIs). Desvenlafaxine, a serotonin‑norepinephrine reuptake inhibitor, has a unique and simple metabolic profile among antidepressants, with minimal potential for DDIs. This review compares the DDI profiles of various antidepressants, highlighting that desvenlafaxine’s low interaction risk makes it a favorable choice when treating depression in patients with multiple chronic illnesses requiring multiple medications.

Fig. 1 Prevalence of depression in patients with chronic physical conditions. (Low Y, et al., 2018)

References

Low Y, et al. Drug-drug interactions involving antidepressants: focus on desvenlafaxine. Neuropsychiatr Dis Treat. 2018;14:567-580.

Does Desvenlafaxine require protection from light during storage?

Yes, it is moderately photosensitive. Prolonged light exposure can cause discoloration and degradation. Store in light-resistant containers in a cool, dry place.

What is the recommended storage temperature for Desvenlafaxine?

Store at controlled room temperature (15-25°C). Avoid excessive heat above 30°C, which can accelerate formation of the cyclic impurity (desvenlafaxine lactam).

Is Desvenlafaxine susceptible to moisture-induced degradation?

It is slightly hygroscopic. Under high humidity, it may absorb moisture and clump, but significant chemical hydrolysis is minimal. Store with desiccant for long-term stability.

How is the impurity O-desmethylvenlafaxine dimer controlled?

This process-related impurity is quantified using a stability-indicating HPLC method, ensuring it remains below ICH qualification thresholds.