Tetrahydrozoline Hydrochloride

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Cat Number

API522485

CAS Number

522-48-5

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Product Detail Description Customer Q&A

CAS Number

522-48-5

EINECS

208-329-3

Storage

Room temperature

Synonyms

2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride

Molecular Formula

C13H17ClN2

Molecular Weight

236.74

Smiles

C1CC(C2=CC=CC=C2C1)C3=NCCN3.Cl

Appearance

White to off-white solid

Melting Point

248-251℃

General Description

Tetrahydrozoline Hydrochloride is an imidazoline derivative that functions as a direct-acting sympathomimetic amine with selective alpha-adrenergic agonist activity. Its chemical structure features a tetrahydroisoquinoline core, which provides vasoconstrictive properties without the cardinal effects associated with non-selective adrenergic stimulation. It is used in ophthalmic and nasal formulations for its decongestant action.

Mechanism of Action

Tetrahydrozoline Hydrochloride activates alpha-1 adrenergic receptors on vascular smooth muscle cells of conjunctival and nasal mucosal blood vessels, causing vasoconstriction. In the eye, this reduces blood flow to the conjunctiva and decreases transudation of fluid across the conjunctival epithelium, thereby reducing conjunctival redness and edema. In nasal mucosa, it causes shrinkage of swollen mucosa and improves nasal patency. The effect is rapid in onset and sustained for several hours.

Application

Tetrahydrozoline Hydrochloride is indicated for the temporary symptomatic relief of ocular redness due to minor eye irritations (e.g., from dust, smoke, swimming, or wearing contact lenses) and for the temporary relief of nasal congestion due to the common cold, sinusitis, or allergic rhinitis.

What is the recommended storage condition for Tetrahydrozoline Hydrochloride?

It should be stored at controlled room temperature in a well-sealed container, protected from moisture and direct light, to maintain its chemical integrity throughout the shelf life.

What documentation is provided with each batch of Tetrahydrozoline Hydrochloride?

Each batch is accompanied by a Certificate of Analysis (COA) covering identity, potency, and relevant purity tests. Safety Data Sheets (SDS) are available upon request.

Does your company offer custom packaging for Tetrahydrozoline Hydrochloride?

Yes, custom pack sizes are available. Specific quantity requirements can be discussed directly with our team to align with your production or research scale.

What grade is available for ophthalmic formulation of Tetrahydrozoline Hydrochloride?

Ophthalmic-grade material meeting stringent sterility and particulate specifications is available; please consult our team for full specification details.