Grepafloxacin Hydrochloride

Inquiry

Cat Number

API161967813

CAS Number

161967-81-3

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Product Detail Description Customer Q&A

CAS Number

161967-81-3

Storage

Store at -20℃

Synonyms

GREPAFLOXACIN HCL;1-Cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid hydrochloride

Molecular Formula

C19H23ClFN3O3

Molecular Weight

395.9

Smiles

CC1CN(CCN1)C2=C(C(=C3C(=C2)N(C=C(C3=O)C(=O)O)C4CC4)C)F.Cl

Appearance

Yellow powder

General Description

Grepafloxacin Hydrochloride is a fluoroquinolone antibacterial agent with a broad spectrum of activity against Gram-positive, Gram-negative, and atypical respiratory pathogens. Its fluorine substituent at the C-6 position and piperazinyl ring at C-7 confer enhanced activity against Streptococcus pneumoniae and improved tissue penetration compared to earlier fluoroquinolones. It was developed specifically for respiratory tract infections.

Mechanism of Action

Grepafloxacin Hydrochloride inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, and repair. By forming a ternary complex with the enzyme and DNA, it prevents DNA supercoiling and strand separation, resulting in irreversible DNA damage and bacterial cell death. Its enhanced activity against Streptococcus pneumoniae is attributed to its improved binding affinity for pneumococcal topoisomerase IV.

Application

Grepafloxacin Hydrochloride is indicated for the treatment of community-acquired respiratory tract infections including acute exacerbations of chronic bronchitis, community-acquired pneumonia, and bacterial sinusitis caused by susceptible organisms.

What is the recommended storage condition for Grepafloxacin Hydrochloride?

It should be stored at -20°C in a well-sealed container, protected from moisture and direct light, to maintain its chemical integrity throughout the shelf life.

Is a Certificate of Analysis (COA) available for Grepafloxacin Hydrochloride?

Yes, a fully verified COA is issued for every batch and can be shared electronically. Additional documentation such as MSDS or impurity profiles may be requested separately.

What quantities of Grepafloxacin Hydrochloride are available for order?

We accommodate orders of varying scale, from small research quantities through bulk commercial supply. Contact our sales team to discuss pack sizes and volume pricing.

What organisms is Grepafloxacin Hydrochloride active against?

Activity spectrum information is documented in available scientific literature. Please contact our technical team for detailed microbiological data relevant to your application.

What quality standards govern the production of Grepafloxacin Hydrochloride?

Production is carried out under GMP-aligned quality systems with full traceability and documented quality controls for each manufacturing run.