Terbutaline Sulfate

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Cat Number

API23031325

CAS Number

23031-32-5

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Product Detail Description Customer Q&A

CAS Number

23031-32-5

EINECS

245-386-3

Storage

Store at room temperature

Synonyms

Terbutaline sulphate; Brethaire; KWD 2019; 1-(3,5-Dihydroxyphenyl)-2-tert-butylaminoethanol sulphate; Brethancer

Molecular Formula

C24H40N2O10S

Molecular Weight

548.6

Smiles

CC(C)(C)NCC(C1=CC(=CC(=C1)O)O)O.CC(C)(C)NCC(C1=CC(=CC(=C1)O)O)O.OS(=O)(=O)O

Appearance

White to off-white crystalline powder

Melting Point

246-248°C

Boiling Point

419.2°C at 760 mmHg

Relative Density

1.171

General Description

Terbutaline sulfate is a synthetic catecholamine derivative with a tertiary butyl group, belonging to the class of beta-2 adrenergic agonists. Its chemical structure is 5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol sulfate.

Mechanism of Action

Terbutaline acts as a selective beta-2 adrenergic receptor agonist, stimulating the production of cyclic AMP (cAMP) in bronchial smooth muscle cells. This leads to bronchodilation, relaxation of the airways, and inhibition of mast cell mediator release. The drug also has a tocolytic effect by relaxing the uterine smooth muscle, although this is not its primary indication.

Application

Terbutaline is indicated for the treatment of bronchial asthma, chronic bronchitis, and emphysema, providing bronchodilation and relief of bronchospasm. It is also used for the management of premature labor (as a tocolytic agent). The drug is effective in improving respiratory function and reducing the frequency of asthma exacerbations.

Does Terbutaline Sulfate require protection from light and oxygen during storage?

Yes, it is sensitive to light and oxygen. Light causes photodegradation and oxygen promotes oxidation of the catechol-like structure. Store in light-resistant, airtight containers.

What is the recommended storage temperature for Terbutaline Sulfate?

Store at controlled room temperature (15-25°C). Avoid excessive heat above 30°C, which accelerates oxidative degradation.

Is Terbutaline Sulfate stable in solution for inhalation and injectable use?

Aqueous solutions are stable when protected from light and stored at room temperature.

How is the impurity terbutaline N-oxide (an oxidative degradation product) monitored?

This degradation product is quantified using a stability-indicating HPLC method with electrochemical detection, ensuring it remains within pharmacopoeial limits.