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Cat Number: API2233543490

GEM-5

CAS Number

2233543-49-0

Description

GEM-5, a gemcitabine-based conjugate incorporating a HIF-1α inhibitor (YC-1) (IC 50 =30 nM), notably suppresses HIF-1α expression while enhancing tumor suppressor p53 expression. It induces apoptosis in A2780 cells and curbs tumor growth.

Molecular Formula

C32H29F2N5O8

Molecular Weight

649.6

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