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Cat Number: API1269440176

Encorafenib

CAS Number

1269440-17-6

Description

Encorafenib (LGX818) is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.

Molecular Formula

C22H27ClFN7O4S

Molecular Weight

540.01

Smiles

COC(=O)N[C@@H](C)CNC1NCCC(N1)-C1CN(NC1-C1CC(Cl)CC(NS(C)(=O)=O)C1F)C(C)C

Purity

0.9974

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 9.3 mg/mL (17.22 mM), In vivo: Suspension. Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.H2O: < 1 mg/mL (insoluble or slightly soluble)Ethanol: 93 mg/mL (172.2 mM)DMSO: 45 mg/mL (83.33 mM)

Relative Density

1.45 (Predicted)

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