Echothiophate Iodide

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Cat Number

API0231647

CAS Number

513-10-0

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Product Detail Description Customer Q&A

CAS Number

513-10-0

EINECS

208-152-1

Synonyms

(2-mercaptoethyl)trimethylammonium iodidie O,O-diethyl phosphorothioate; O,O-diethyl S-2-trimethylammonium ethylphosphonothiolate iodide

Molecular Formula

C9H23INO3PS

Molecular Weight

383.2

Smiles

O=P(OCC)(OCC)SCCN+(C)C.[I-]

Melting Point

138°C

General Description

Echothiophate iodide is a potent, long-acting organophosphate compound used as a miotic agent in ophthalmology.As an irreversible cholinesterase inhibitor, it represents one of the most potent classes of glaucoma medications, though its use has significantly declined with the advent of safer agents.

Mechanism of Action

Echothiophate iodide acts as an irreversible inhibitor of acetylcholinesterase, binding covalently to the enzyme's active site. By inactivating cholinesterase, it prevents the hydrolysis of endogenously liberated acetylcholine in parasympathetically innervated ocular structures.

Application

Echothiophate iodide is indicated for the treatment of open-angle glaucoma and accommodative esotropia. In glaucoma management, it provides effective round-the-clock intraocular pressure control, though it is now reserved for refractory cases due to its side effect profile. For accommodative esotropia in pediatric patients, it is used diagnostically and therapeutically to correct ocular deviation.

Is Echothiophate Iodide extremely sensitive to moisture during storage?

Yes, Echothiophate Iodide is highly hygroscopic and susceptible to hydrolysis. It must be stored under strict anhydrous conditions, preferably with desiccant in a tightly sealed container.

Does refrigeration slow down the degradation of Echothiophate Iodide?

Absolutely. Storage at 2-8°C is critical to retard hydrolysis and maintain its chemical integrity, as even trace moisture can accelerate decomposition at higher temperatures.

What type of packaging is used to protect Echothiophate Iodide during transit?

We use triple-laminated aluminum foil bags with integrated desiccant pouches, sealed under vacuum or nitrogen, to provide an absolute moisture barrier during transport.

How is the potency of Echothiophate Iodide verified over its shelf life?

Potency is monitored via a specific stability-indicating HPLC method that can distinguish the parent compound from its major degradation products, ensuring therapeutic efficacy.