Demecarium Bromide

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Cat Number

API56940

CAS Number

56-94-0

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Product Detail Description Customer Q&A

CAS Number

56-94-0

EINECS

200-301-9

Storage

Under -20°C

Molecular Formula

C32H52Br2N4O4

Molecular Weight

716.6

Smiles

CN(CCCCCCCCCCN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C)C(=O)OC2=CC=CC(=C2)[N+](C)(C)C.[Br-].[Br-]

Appearance

White solid

Melting Point

162-167℃

General Description

Demecarium Bromide is a long-acting anticholinesterase agent of the quaternary ammonium carbamate class, primarily developed for ophthalmic use. Its bis-quaternary structure consists of two physostigmine-like carbamate units linked by a decamethylene chain, which confers prolonged cholinesterase inhibitory activity.

Mechanism of Action

Demecarium Bromide irreversibly inhibits acetylcholinesterase and pseudocholinesterase by carbamylating the active site serine residue, preventing hydrolysis of acetylcholine at cholinergic synapses. This prolonged enzyme inhibition results in sustained accumulation of acetylcholine at neuromuscular junctions and parasympathetic nerve endings.

Application

Used in ophthalmology for the treatment of accommodative esotropia and certain types of glaucoma. Demecarium Bromide is a long-acting cholinesterase inhibitor that produces sustained miosis and contraction of the ciliary muscle, particularly useful in the management of accommodative strabismus and angle-closure glaucoma adjunctive therapy.

What makes Demecarium Bromide unique among ophthalmic cholinesterase inhibitors?

Demecarium Bromide is a bis-quaternary carbamate with exceptionally long-lasting cholinesterase inhibition, far exceeding that of physostigmine or neostigmine, providing sustained therapeutic effect.