Methyldopate Hydrochloride

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Cat Number

API2508794

CAS Number

2508-79-4

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Product Detail Description Customer Q&A

CAS Number

2508-79-4

EINECS

219-720-3

Storage

2-8℃

Synonyms

Ethyl methyldopate hydrochloride;(2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methyl-propionic acid ethyl ester hydrochloride

Molecular Formula

C12H18ClNO4

Molecular Weight

275.73

Smiles

CCOC(=O)[C@](C)(CC1=CC(=C(C=C1)O)O)N.Cl

Appearance

Crystalline powder

General Description

Methyldopate Hydrochloride is the ester prodrug of methyldopa, an centrally-acting alpha-2 adrenergic agonist used primarily in the management of hypertension, including hypertension in pregnancy. The esterification to methyldopate improves aqueous solubility and allows for intravenous administration, providing a useful option for hypertensive emergencies when oral intake is not feasible.

Mechanism of Action

Methyldopate Hydrochloride is hydrolyzed in plasma to methyldopa (alpha-methyl-DOPA), which acts as a false neurotransmitter. Alpha-methyldopa is decarboxylated by aromatic L-amino acid decarboxylase (ALAAD) to alpha-methylnorepinephrine (alpha-MN), a potent agonist at central alpha-2 adrenergic receptors. Activation of central alpha-2 receptors in the brainstem reduces sympathetic outflow, decreasing peripheral vascular resistance, heart rate, and blood pressure without causing significant reduction in renal blood flow.

Application

Methyldopate Hydrochloride is indicated for the treatment of hypertensive crises, particularly in hospitalized patients, and is considered one of the preferred antihypertensives for managing severe hypertension in pregnancy (gestational hypertension and pre-eclampsia) due to its extensive safety data in this population.

What is the recommended storage condition for Methyldopate Hydrochloride?

It should be stored at 2-8°C in a well-sealed container, protected from moisture and direct light, to maintain its chemical integrity throughout the shelf life.

Can we obtain batch-specific analytical data for Methyldopate Hydrochloride?

Batch-specific COA documents are standard with every shipment. Additional analytical reports, including HPLC chromatograms or spectral data, may be provided upon request.

What is the minimum order quantity (MOQ) for Methyldopate Hydrochloride?

Flexible MOQ options are available to support both early-stage research and large-scale manufacturing needs. Our team can tailor order quantities to match your specific requirements.

Is Methyldopate Hydrochloride available in multiple salt forms?

The standard commercial salt form is supplied; for inquiries about alternative salt forms or polymorphs, please contact our technical team.

What quality standards govern the production of Methyldopate Hydrochloride?

Production is carried out under GMP-aligned quality systems with full traceability and documented quality controls for each manufacturing run.