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Diphenoxylate Hydrochloride

Diphenoxylate Hydrochloride

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Cat Number
API3810808
CAS Number
3810-80-8

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CAS Number
3810-80-8
Synonyms
Diphenoxylate HCl
Molecular Formula
C30H33ClN2O2
Molecular Weight
489
Smiles
CCOC(=O)C1(CCN(CC1)CCC(C#N)(C2=CC=CC=C2)C3=CC=CC=C3)C4=CC=CC=C4.Cl
General Description
Diphenoxylate Hydrochloride is a piperidine derivative structurally related to meperidine, classified as an opioid antidiarrheal agent acting locally on the gastrointestinal tract with minimal central opioid effects.
Mechanism of Action
Diphenoxylate activates mu-opioid receptors in the intestinal myenteric plexus, enhancing segmental smooth muscle tone and inhibiting propulsive peristalsis while reducing intestinal fluid secretion, increasing stool consistency.
Application
Used in the symptomatic treatment of acute and chronic diarrhea. Diphenoxylate Hydrochloride is indicated for non-infective diarrhea, functional diarrhea, and adjunctive management of inflammatory bowel disease diarrhea.

How does Diphenoxylate differ from loperamide in diarrhea management?

Diphenoxylate is often combined with subtherapeutic atropine to discourage misuse, while loperamide has even lower central opioid penetration.

What storage conditions are required?

Store at room temperature in a tightly sealed container, protected from light and moisture.

What purity grade is available?

It is supplied as a high-purity grade suitable for R&D and pharmaceutical manufacturing.

Can packaging and order quantities be customized?

Yes, both packaging formats and order quantities can be tailored to meet specific R&D and production needs.
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