Diphenoxylate Hydrochloride

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Cat Number

API3810808

CAS Number

3810-80-8

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Product Detail Description Customer Q&A

CAS Number

3810-80-8

Synonyms

Diphenoxylate HCl

Molecular Formula

C30H33ClN2O2

Molecular Weight

489

Smiles

CCOC(=O)C1(CCN(CC1)CCC(C#N)(C2=CC=CC=C2)C3=CC=CC=C3)C4=CC=CC=C4.Cl

General Description

Diphenoxylate Hydrochloride is a piperidine derivative structurally related to meperidine, classified as an opioid antidiarrheal agent acting locally on the gastrointestinal tract with minimal central opioid effects.

Mechanism of Action

Diphenoxylate activates mu-opioid receptors in the intestinal myenteric plexus, enhancing segmental smooth muscle tone and inhibiting propulsive peristalsis while reducing intestinal fluid secretion, increasing stool consistency.

Application

Used in the symptomatic treatment of acute and chronic diarrhea. Diphenoxylate Hydrochloride is indicated for non-infective diarrhea, functional diarrhea, and adjunctive management of inflammatory bowel disease diarrhea.