Isopropamide Iodide

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Cat Number

API0231635

CAS Number

71-81-8

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Product Detail Description Customer Q&A

CAS Number

71-81-8

EINECS

200-766-8

Storage

Store at room temperature

Synonyms

Darbid; Dipramid; Dipramide; Piaccamide; Priamide; Priazimide

Molecular Formula

C23H33IN2O

Molecular Weight

480.4

Smiles

CC(C)[N+](C)(CCC(C1=CC=CC=C1)(C2=CC=CC=C2)C(=O)N)C(C)C.[I-]

Appearance

White to off-white crystalline powder

Melting Point

199℃

Relative Density

1.2711 (Predicted)

General Description

Isopropamide iodide is a quaternary ammonium anticholinergic agent that was used to reduce gastric acid secretion and gastrointestinal motility. It contains iodine, providing weak radio‑opacity for imaging purposes.

Mechanism of Action

Isopropamide competitively blocks muscarinic acetylcholine receptors in the gastrointestinal tract, reducing basal and stimulated gastric acid secretion, decreasing intestinal motility, and relaxing smooth muscle. The quaternary ammonium structure limits central nervous system penetration, reducing central anticholinergic side effects. However, it still causes peripheral effects such as dry mouth, blurred vision, and urinary retention.

Application

Isopropamide was indicated as adjunctive therapy for peptic ulcer disease, gastritis, and irritable bowel syndrome to reduce hypermotility and hypersecretion. It was also used to control diarrhea.

Does Isopropamide Iodide require protection from light during storage?

Yes, it is photosensitive. Light exposure can cause photodegradation and release of iodine (discoloration). Store in light-resistant, tightly sealed containers, preferably amber glass.

What is the recommended storage temperature for Isopropamide Iodide?

Store at controlled room temperature (15-25°C). Avoid excessive heat above 30°C, which accelerates decomposition and free iodine formation.

Is Isopropamide Iodide stable under high-humidity conditions?

It is slightly hygroscopic but chemically stable. However, moisture may promote surface discoloration due to trace iodine release. Store with desiccant.

How is the free iodine content monitored during stability?

Free iodine is quantified using a validated colorimetric or titrimetric method, ensuring it remains below pharmacopoeial limits (typically ≤ 0.1%).