Paramethasone Acetate

Inquiry

Cat Number

API1597826

CAS Number

1597-82-6

If you have any other questions, please contact our experts.

Product Detail Description Customer Q&A

CAS Number

1597-82-6

EINECS

216-486-4

Storage

Store at room temperature

Synonyms

Monocortin; Haldrone; Paramethasone 21-acetate; Haldrate; Dilar; 8X50N88ZDP; DTXSID8023422

Molecular Formula

C24H31FO6

Molecular Weight

434.5

Smiles

C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@H]3[C@H](C[C@@]2([C@]1(C(=O)COC(=O)C)O)C)O)C)F

Melting Point

148℃

Boiling Point

584.2℃ at 760 mmHg (Predicted)

Relative Density

1.29 (Predicted)

General Description

Paramethasone acetate is a synthetic glucocorticoid with potent anti‑inflammatory activity and minimal mineralocorticoid effects. It is available as oral tablets for systemic use and has a longer duration of action than prednisone. The drug is a fluorinated corticosteroid, structurally related to dexamethasone, but is now rarely prescribed.

Mechanism of Action

Paramethasone binds to cytoplasmic glucocorticoid receptors, and the complex translocates to the nucleus to regulate gene transcription. It suppresses the production of pro‑inflammatory cytokines (IL‑1, IL‑6, TNF‑alpha), reduces phospholipase A2 expression, and inhibits NF‑κB activation. These actions result in profound immunosuppression, anti‑inflammation, and stabilization of lysosomal membranes.

Application

Paramethasone was indicated for a wide range of inflammatory and autoimmune conditions, including rheumatoid arthritis, asthma, allergic disorders, and dermatologic diseases. It was also used as adjunctive therapy in certain cancers and for cerebral edema.

Does Paramethasone Acetate require protection from light during long-term storage?

Yes, it is photosensitive. Light exposure can cause photodegradation and discoloration. Store in light-resistant containers, preferably amber glass.

What is the recommended storage temperature for Paramethasone Acetate?

Store at controlled room temperature (15-25°C). Avoid excessive heat above 30°C, which can accelerate hydrolysis of the acetate ester to paramethasone free alcohol.

Is Paramethasone Acetate stable under high-humidity conditions?

It is slightly hygroscopic. Under high humidity, it may absorb moisture and hydrolyze. Store in tightly sealed containers with desiccant for long-term stability.

How is the impurity paramethasone (free alcohol) monitored during stability?

This primary hydrolysis product is specifically quantified using a stability-indicating HPLC method, ensuring it remains below USP/EP limits.