Desflurane

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Cat Number

API57041675

CAS Number

57041-67-5

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Product Detail Description Scientific Support Customer Q&A

CAS Number

57041-67-5

Synonyms

2-(difluoromethoxy)-1,1,1,2-tetrafluoroethane

Molecular Formula

C3H2F6O

Molecular Weight

168.04

Smiles

C(C(F)(F)F)(OC(F)F)F

Appearance

Liquid

Boiling Point

23-24℃

Relative Density

1.47

General Description

Desflurane is a fluorinated inhalation anesthetic of the halogenated ether class, distinguished by an extremely low blood-gas partition coefficient that enables exceptionally rapid induction and emergence from anesthesia.

Mechanism of Action

Desflurane enhances GABA-A receptor-mediated inhibitory chloride conductance while inhibiting NMDA and glycine receptors, producing reversible central nervous system depression with rapid pharmacokinetic profile.

Application

Used in the induction and maintenance of general anesthesia. Desflurane is indicated for outpatient and inpatient anesthesia, particularly suitable for procedures requiring rapid emergence and recovery.

Desflurane-based anesthesia provided neurologic protection in a piglet model of deep hypothermic circulatory arrest. Arterial desflurane concentrations reached nearly 9 percent within 10 minutes during cardiopulmonary bypass cooling and decreased rapidly to approximately 2 percent within 10 minutes after drug withdrawal during rewarming. The desflurane group demonstrated significantly better neurologic performance scores on postoperative day 2 compared to the fentanyl group. Histologic examination revealed less tissue damage and fewer dead neurons in the neocortex of desflurane-treated animals. These findings demonstrated that desflurane conferred neurologic protection against ischemic injury associated with CPB and DHCA, suggesting potential application in infant cardiac surgery to reduce neurologic complications.

Fig. 1 Postoperative neurologic scores (days 1 and 2) in desflurane vs. fentanyl groups. (Kurth C D.; et al. 2001)

References

Kurth C D, et al. Desflurane confers neurologic protection for deep hypothermic circulatory arrest in newborn pigs. Anesthesiology, 2001, 95(4): 959-964.

What makes Desflurane unique among inhalation anesthetics?

Desflurane has the lowest blood-gas partition coefficient of all clinical anesthetics, enabling the fastest induction and emergence, ideal for day-surgery settings.