An ISO9001 Certified Supplier of Pharmaceutical Ingredients and Specialty Chemicals

N-desmethyl Regorafenib N-oxide

Inquiry

Cat Number

API835621120

CAS Number

835621-12-0

If you have any other questions, please contact our experts.

Product Detail

CAS Number

835621-12-0

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Description

N-Desmethyl Regorafenib N-oxide, an active metabolite of the multi-kinase inhibitor regorafenib, originates through the action of the cytochrome P450 (CYP) isoform CYP3A4. This compound demonstrates efficacy in vitro by inhibiting key enzymes such as VEGFR2, Tie2, c-Kit, and B-RAF, and it exhibits tumor growth inhibition in HT-29 and MDA-MB-231 mouse xenograft models at a dosage of 1 mg/kg.

Molecular Formula

C20H13ClF4N4O4

Molecular Weight

484.79

You Might Also Like