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N-desmethyl Regorafenib N-oxide

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Cat Number

API835621120

CAS Number

835621-12-0

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Product Detail

CAS Number

835621-12-0

Description

N-Desmethyl Regorafenib N-oxide, an active metabolite of the multi-kinase inhibitor regorafenib, originates through the action of the cytochrome P450 (CYP) isoform CYP3A4. This compound demonstrates efficacy in vitro by inhibiting key enzymes such as VEGFR2, Tie2, c-Kit, and B-RAF, and it exhibits tumor growth inhibition in HT-29 mouse xenograft models at a dosage of 1 mg/kg.

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