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Cat Number: API2252403566

(S)-AMG-510

CAS Number

2252403-56-6

Description

(S)-AMG-510 is the S-type compound of AMG-510 (Sotorasib), which effectively and selectively inhibits KRASG12C through covalent interaction with mutant cysteine, thereby promoting clinical efficacy in KRASG12C tumors.

Molecular Formula

C30H30F2N6O3

Molecular Weight

560.59

Smiles

O=C1N(C=2C(C(=N1)N3[C@@H](C)CN(C(C=C)=O)CC3)=CC(F)=C(N2)C4=C(F)C=CC=C4O)C5=C(C(C)C)N=CC=C5C

Purity

0.9857

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

DMSO: 5.61 mg/mL (10 mM)

Relative Density

1.36 (Predicted)

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