Betamethasone Sodium Phosphate

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Cat Number

API151735

CAS Number

151-73-5

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CAS Number

151-73-5

EINECS

205-797-0

Storage

Room temperature

Synonyms

Betamethasone 21-phosphate disodium salt

Molecular Formula

C22H28FNa2O8P

Molecular Weight

516.4

Smiles

C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)COP(=O)([O-])[O-])O)C)O)F)C.[Na+].[Na+]

Appearance

White to off-white solid

Melting Point

206-211℃

General Description

Betamethasone Sodium Phosphate is a water-soluble ester salt of a synthetic fluorinated glucocorticoid. It provides rapid onset of anti-inflammatory activity due to its high water solubility enabling intravenous administration.

Mechanism of Action

Betamethasone binds cytosolic glucocorticoid receptors and the complex translocates to the nucleus, inducing anti-inflammatory gene products while suppressing pro-inflammatory cytokines through transcriptional and post-transcriptional mechanisms.

Application

Used in the treatment of severe inflammatory and autoimmune conditions. Betamethasone Sodium Phosphate is indicated for severe allergies, adrenal insufficiency, rheumatoid arthritis, dermatological conditions, and for fetal lung maturation acceleration.

Betamethasone sodium phosphate was intercalated into layered double hydroxide single-layer nanosheets via a coassembly route driven by electrostatic attraction between positively charged LDH nanosheets and BMP anions. The resulting BMP-LDH nanohybrids were then coated with liposomes composed of lecithin and cholesterol through a reverse evaporation method to prepare BLN@LS nanocomposites. The nanocomposites exhibited excellent water re-dispersity and enhanced drug sustained-release performance compared to uncoated BLNs. Drug release from the nanocomposites was pH-dependent and followed the pseudo-second-order kinetic model, with intraparticle diffusion as the rate-limiting step. This liposome-coating strategy effectively combined the beneficial features of LDH carriers and liposomal vectors while mitigating their individual drawbacks.

Fig. 2 Preparation of betamethasone sodium phosphate-loaded double hydroxide single-layer nanosheets. (Zhang Y.; et al. 2017)

References

Zhang Y, et al. Preparation and characterization of (betamethasone sodium phosphate intercalated layered double hydroxide)@ liposome nanocomposites. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2017, 529: 824-831.

What advantage does the sodium phosphate salt provide?

The sodium phosphate ester provides enhanced water solubility for rapid intravenous administration, enabling immediate glucocorticoid activity in emergency settings.