Esomeprazole Sodium

Inquiry

Cat Number

API161796787

CAS Number

161796-78-7

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Product Detail

CAS Number

161796-78-7

EINECS

620-470-6

Synonyms

Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (s)-omeprazole sodium salt sodium;5-methoxy-2-[(S)-(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]benzimidazol-3-ide

Description

Esomeprazole Sodium is the sodium salt of the S-isomer of omeprazole, with gastric proton pump inhibitor activity. In the acidic compartment of parietal cells, esomeprazole is protonated and converted into the active achiral sulfenamide; the active sulfenamide forms one or more covalent disulfide bonds with the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting its activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production. H+/K+ ATPase is an integral membrane protein of the gastric parietal cell.

Molecular Formula

C17H18N3NaO3S

Molecular Weight

367.4

Appearance

Pale Beige to Beige Solid

Melting Point

196-200 ℃

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