Benzonatate

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Cat Number

API104314

CAS Number

104-31-4

For research use only. We do not supply to patients.

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Product Detail Description Customer Q&A

CAS Number

104-31-4

EINECS

203-194-7

Storage

Store at room temperature

Synonyms

Benzononatine; Tessalon; Benzonatatum; Benzonatato; Tessalon Perles; Zonatuss

Molecular Formula

C30H53NO11

Molecular Weight

603.7

Smiles

CCCCNC1=CC=C(C=C1)C(=O)OCCOCCOCCOCCOCCOCCOCCOCCOCCOC

Appearance

Typically exists as solid

Boiling Point

649.0±55.0°C at 760 mmHg (Predicted)

Relative Density

1.096±0.06 (Predicted)

General Description

Benzonatate is a synthetic derivative of tetracaine, a local anesthetic, with a polyethylene glycol chain attached to the benzoic acid moiety. Its chemical structure is a butylamino benzoate with a polyethylene glycol chain, forming a viscous liquid that is practically insoluble in water but soluble in organic solvents. Benzonatate is an antitussive agent with a unique chemical structure.

Mechanism of Action

Benzonatate acts by anesthetizing the stretch receptors in the lungs, bronchi, and pleura, which are responsible for the cough reflex. It reduces the sensitivity of these receptors to stimuli, thereby suppressing the cough reflex without affecting the respiratory center. The drug also has a mild local anesthetic effect on the pharynx, contributing to its efficacy.

Application

Benzonatate is indicated for the relief of cough associated with the common cold, bronchitis, and other respiratory conditions. It is effective in reducing the frequency and intensity of cough, particularly non-productive cough.

Does Benzonatate require protection from light during long-term storage?

Yes, it is photosensitive. UV exposure can cause photodegradation of the polyethylene glycol side chain. Store in light-resistant containers, preferably amber glass.