Benoxinate Hydrochloride

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Cat Number

API5987826

CAS Number

5987-82-6

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CAS Number

5987-82-6

EINECS

227-808-8

Storage

2-8℃

Synonyms

4-AMINO-3-BUTOXYBENZOIC ACID DIETHYLAMINOETHYL ESTER HYDROCHLORIDE;BENZOIC ACID, 4-AMINO-3-BUTOXY-, 2-(DIETHYLAMINO)ETHYL ESTER, MONOHYDROCHLORIDE

Molecular Formula

C17H29ClN2O3

Molecular Weight

344.9

Smiles

CCCCOC1=C(C=CC(=C1)C(=O)OCCN(CC)CC)N.Cl

Appearance

White to off-white solid

Melting Point

157-160℃

General Description

Benoxinate Hydrochloride is a synthetic ester-type local anesthetic of the aminobenzoate class designed for ophthalmic surface anesthesia, characterized by rapid onset and short duration with minimal corneal toxicity.

Mechanism of Action

Benoxinate reversibly blocks voltage-gated sodium channels in neuronal membranes, preventing sodium influx and inhibiting membrane depolarization, providing effective surface anesthesia with minimal systemic absorption.

Application

Used in ophthalmology for topical surface anesthesia. Benoxinate Hydrochloride is indicated for tonometry, foreign body removal, corneal scraping, and short diagnostic procedures requiring corneal anesthesia.

What makes Benoxinate preferred for ophthalmic procedures?

Benoxinate offers rapid onset within minutes and lower corneal toxicity compared to tetracaine, making it suitable for repeated ophthalmic examinations.