Methixene Hydrochloride

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Cat Number

API7081405

CAS Number

7081-40-5

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Product Detail Description Customer Q&A

CAS Number

7081-40-5

Synonyms

1-methyl-3-(9H-thioxanthen-9-ylmethyl)-, hydrochloride, hydrate

Molecular Formula

C20H26ClNOS

Molecular Weight

363.9

Smiles

CN1CCCC(C1)CC2C3=CC=CC=C3SC4=CC=CC=C24.O.Cl

General Description

Methixene Hydrochloride is an anticholinergic and antispasmodic agent of the thioxanthene class, structurally related to the antipsychotic drug thiothixene but designed for peripheral anticholinergic effects. It competitively antagonizes muscarinic acetylcholine receptors on gastrointestinal smooth muscle, reducing acetylcholine-mediated peristaltic contractions and gastrointestinal spasms, while also exerting mild antihistamine effects.

Mechanism of Action

Methixene Hydrochloride acts as a competitive antagonist at muscarinic acetylcholine receptors (M1, M2, M3 subtypes) in the smooth muscle of the gastrointestinal tract, urinary bladder, and other organs. By blocking the parasympathetic cholinergic transmission that drives smooth muscle contractions, it reduces gastrointestinal motility, intestinal spasms, and visceral pain associated with functional bowel disorders. Its antihistamine properties provide additional antipruritic and mild sedative effects.

Application

Methixene Hydrochloride is indicated for the symptomatic treatment of gastrointestinal spasm, irritable bowel syndrome (IBS), intestinal colic, and other functional gastrointestinal disorders characterized by hypermotility and visceral hypersensitivity. It may also be used in the management of urinary frequency and urgency associated with overactive bladder.

What is the recommended storage condition for Methixene Hydrochloride?

It should be stored at controlled room temperature in a well-sealed container, protected from moisture and direct light, to maintain its chemical integrity throughout the shelf life.

Can we obtain batch-specific analytical data for Methixene Hydrochloride?

Batch-specific COA documents are standard with every shipment. Additional analytical reports, including HPLC chromatograms or spectral data, may be provided upon request.

What is the minimum order quantity (MOQ) for Methixene Hydrochloride?

Flexible MOQ options are available to support both early-stage research and large-scale manufacturing needs. Our team can tailor order quantities to match your specific requirements.

Does Methixene Hydrochloride have pharmacopoeial monograph compliance?

Material meeting applicable pharmacopoeial specifications or equivalent internal quality standards can be supplied; please contact us with your specific compendial requirements.

Is Methixene Hydrochloride suitable for use in regulated pharmaceutical processes?

Yes, it is manufactured under quality standards consistent with regulated pharmaceutical applications, including in-process controls and release testing aligned with industry requirements.