Arbutamine Hydrochloride

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Cat Number

API125251663

CAS Number

125251-66-3

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Product Detail Description Customer Q&A

CAS Number

125251-66-3

Molecular Formula

C18H24ClNO4

Molecular Weight

353.8

Smiles

C1=CC(=CC=C1CCCCNC[C@@H](C2=CC(=C(C=C2)O)O)O)O.Cl

Melting Point

55-58℃

General Description

Arbutamine Hydrochloride is a synthetic catecholamine derivative with non-catechol, nonglycosylated structure designed as a pharmacological stress agent for cardiac diagnostic testing. Its molecular design reduces susceptibility to catechol-O-methyltransferase (COMT)-mediated metabolism, providing a longer duration of action compared to natural catecholamines, while maintaining strong beta-adrenergic agonist activity.

Mechanism of Action

Arbutamine Hydrochloride primarily activates beta-1 adrenergic receptors in the myocardium, increasing cardiac chronotropy (heart rate), inotropy (contractility), and dromotropy (conduction velocity). The resulting increase in myocardial oxygen demand mimics the physiological stress of exercise, making it useful for cardiac stress testing. Its enhanced metabolic stability allows for programmable infusion rates, producing a controlled and reproducible hemodynamic response for diagnostic evaluation of coronary artery disease.

Application

Arbutamine Hydrochloride is used as a pharmacological stress agent for diagnostic cardiac testing in patients unable to perform adequate physical exercise.

What is the recommended storage condition for Arbutamine Hydrochloride?

It should be stored at controlled room temperature in a well-sealed container, protected from moisture and direct light, to maintain its chemical integrity throughout the shelf life.

Can we obtain batch-specific analytical data for Arbutamine Hydrochloride?

Batch-specific COA documents are standard with every shipment. Additional analytical reports, including HPLC chromatograms or spectral data, may be provided upon request.

What quantities of Arbutamine Hydrochloride are available for order?

We accommodate orders of varying scale, from small research quantities through bulk commercial supply. Contact our sales team to discuss pack sizes and volume pricing.

What is the standard particle size of Arbutamine Hydrochloride supplied?

Standard commercial grades are supplied; custom particle size specifications are available upon request for specific formulation needs.