Benzoxonium Chloride

Inquiry

Cat Number

API19379909

CAS Number

19379-90-9

If you have any other questions, please contact our experts.

Product Detail Description Customer Q&A

CAS Number

19379-90-9

EINECS

243-008-1

Storage

Store at room temperature

Synonyms

Bradophen; Absonal; Cohortan; Beloran; Lomades; Bactofen; Bialcol; Orofar; Katanol C12

Molecular Formula

C23H42ClNO2

Molecular Weight

400

Smiles

CCCCCCCCCCCC[N+](CCO)(CCO)CC1=CC=CC=C1.[Cl-]

Appearance

White to pale yellow solid

Melting Point

107-109°C

General Description

Benzoxonium chloride is a quaternary ammonium compound (QAC) functioning as a broad-spectrum antiseptic. Its cationic quaternary ammonium group and lipophilic alkyl chain enable potent membrane-active biocidal activity.

Mechanism of Action

The cationic headgroup of the molecule is electrostatically attracted to the negatively charged components of the microbial cell envelope, leading to disruption of the cell membrane. This interaction causes leakage of intracellular contents, protein denaturation, and inactivation of certain bacterial enzymes, ultimately resulting in cell death. The effect is concentration-dependent, exhibiting both bactericidal and bacteriostatic properties.

Application

Benzoxonium chloride is employed as a topical antiseptic and disinfectant for the prevention and treatment of superficial infections. It suppresses the growth of microorganisms on skin and mucous membranes, including in oral cavity applications. It has also been investigated for its anti-infective activity against parasitic organisms.

Does Benzoxonium Chloride require protection from light during storage?

Yes, it is photosensitive. Light exposure can cause photodegradation and discoloration. Store in light-resistant containers, preferably original opaque packaging.

What is the recommended storage temperature for Benzoxonium Chloride?

Store at controlled room temperature (15-25°C). Avoid excessive heat above 30°C, which can accelerate decomposition and loss of quaternary ammonium activity.

Is Benzoxonium Chloride stable in solution for antiseptic formulations?

Aqueous solutions are stable when protected from light and stored at room temperature.

How is the impurity 2-benzyloxyethyl chloride (a potential genotoxic impurity) monitored?

We use a sensitive GC-MS method to monitor this process-related impurity, ensuring it remains below the threshold of toxicological concern.