Ambenonium Chloride

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Cat Number

API115797

CAS Number

115-79-7

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Product Detail Description Customer Q&A

CAS Number

115-79-7

EINECS

204-107-5

Storage

Room temperature

Synonyms

(2-chlorobenzyl)-[2-[[2-[2-[(2-chlorobenzyl)-diethyl-ammonio]ethylamino]-2-keto-acetyl]amino]ethyl]-diethyl-ammonium dichloride

Molecular Formula

C28H42Cl4N4O2

Molecular Weight

608.5

Smiles

CC[N+](CC)(CCNC(=O)C(=O)NCC[N+](CC)(CC)CC1=CC=CC=C1Cl)CC2=CC=CC=C2Cl.[Cl-].[Cl-]

Appearance

White to off-white powder

Melting Point

196-199℃

General Description

Ambenonium Chloride is a synthetic quaternary ammonium anticholinesterase compound. It is structurally characterized by two benzyl groups and two 2-chloroethyl groups connected through a diamine linker, forming a bis-quaternary ammonium salt that reversibly inhibits acetylcholinesterase.

Mechanism of Action

Ambenonium Chloride reversibly inhibits acetylcholinesterase by binding electrostatically to the anionic site and through its carbamoyl or quaternary nitrogen to the esteratic site, preventing the hydrolysis of acetylcholine at neuromuscular junctions and cholinergic synapses.

Application

Indicated for the treatment of myasthenia gravis. Ambenonium Chloride is a long-acting bis-quaternary anticholinesterase agent that reversibly inhibits acetylcholinesterase at neuromuscular junctions, increasing acetylcholine availability and improving muscle strength in patients with neuromuscular junction disorders.

What distinguishes Ambenonium Chloride from neostigmine?

Ambenonium Chloride is a bis-quaternary compound with a longer duration of action due to its high affinity for the acetylcholinesterase anionic site, providing sustained cholinergic support.