Orphenadrine Citrate

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Cat Number

API4682364

CAS Number

4682-36-4

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Product Detail Description Customer Q&A

CAS Number

4682-36-4

EINECS

225-137-5

Storage

2-8℃

Synonyms

beta-dimethylaminoethyl2-methylbenzhydrylethercitrate;N,N-Dimethyl-2-[(2-methylphenyl)phenylmethoxy]ethanamineCitrateSalt

Molecular Formula

C24H31NO8

Molecular Weight

461.5

Smiles

CC1=CC=CC=C1C(C2=CC=CC=C2)OCCN(C)C.C(C(=O)O)C(CC(=O)O)(C(=O)O)O

Appearance

White to off-white solid

Melting Point

132-134℃

General Description

Orphenadrine Citrate is a centrally acting skeletal muscle relaxant and anticholinergic agent used in the management of acute musculoskeletal pain and as an adjunct in Parkinson's disease therapy. Its chemical structure is related to diphenhydramine with an ortho-methyl substitution on one phenyl ring, conferring both antihistamine and anticholinergic properties. The citrate salt provides enhanced aqueous solubility for oral and parenteral administration.

Mechanism of Action

Orphenadrine Citrate exerts its muscle relaxant and antiparkinsonian effects through multiple mechanisms: central anticholinergic activity blocking muscarinic acetylcholine receptors in the corpus striatum, restoring the balance between dopaminergic and cholinergic transmission that is disrupted in Parkinson's disease; and antihistamine properties contributing to CNS depression and sedation. Its analgesic effect in musculoskeletal conditions is thought to be partially mediated through NMDA receptor antagonism.

Application

Orphenadrine Citrate is indicated for the symptomatic relief of acute, painful musculoskeletal conditions such as muscle strains, sprains, and associated muscle spasms, as well as for the management of tremor, rigidity, and bradykinesia in Parkinson's disease and drug-induced extrapyramidal symptoms.

What is the recommended storage condition for Orphenadrine Citrate?

It should be stored at 2-8°C in a well-sealed container, protected from moisture and direct light, to maintain its chemical integrity throughout the shelf life.

Is a Certificate of Analysis (COA) available for Orphenadrine Citrate?

Yes, a fully verified COA is issued for every batch and can be shared electronically. Additional documentation such as MSDS or impurity profiles may be requested separately.

Does your company offer custom packaging for Orphenadrine Citrate?

Yes, custom pack sizes are available. Specific quantity requirements can be discussed directly with our team to align with your production or research scale.

What is the standard particle size of Orphenadrine Citrate supplied?

Standard commercial grades are supplied; custom particle size specifications are available upon request for specific formulation needs.

What quality standards govern the production of Orphenadrine Citrate?

Production is carried out under GMP-aligned quality systems with full traceability and documented quality controls for each manufacturing run.