Betamethasone Acetate

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Cat Number

API987246

CAS Number

987-24-6

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CAS Number

987-24-6

EINECS

213-578-6

Storage

2-8℃

Synonyms

Betamethasone 21-acetate;(11β,16β)-21-(Acetyloxy)-9-fluoro-11,17-dihydroxy-16-Methylpregna-1,4-diene-3,20-dione

Molecular Formula

C24H31FO6

Molecular Weight

434.5

Smiles

C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)COC(=O)C)O)C)O)F)C

Appearance

White to off-white solid

Melting Point

200-220℃

Boiling Point

579℃

Relative Density

1.09

pKa

12.08

General Description

Betamethasone Acetate is the 21-acetate ester of betamethasone, a synthetic fluorinated glucocorticoid. The acetate ester provides reduced aqueous solubility compared to betamethasone sodium phosphate, resulting in a depot effect that extends the duration of glucocorticoid activity at the site of administration.

Mechanism of Action

Betamethasone Acetate binds to intracellular glucocorticoid receptors, and the receptor-ligand complex translocates to the nucleus to modulate gene transcription. It suppresses the expression of pro-inflammatory cytokines (IL-1, IL-6, TNF-alpha), adhesion molecules, and cyclooxygenase-2, while upregulating anti-inflammatory mediators.

Application

Indicated for the treatment of inflammatory and pruritic dermatoses. Betamethasone Acetate is a synthetic fluorinated glucocorticoid with a depot effect from its acetate ester, providing prolonged anti-inflammatory activity at the injection site for localized steroid-responsive conditions.

Betamethasone acetate-loaded polyvinyl alcohol nanospheres were prepared by oil-in-water emulsion method followed by different cycles of freeze-thawing process. Transmission electron microscopy confirmed successful fabrication of nanospheres. The freeze-thawing treatment physically cross-linked the PVA matrix, and increasing the number of freeze-thaw cycles from 1 to 4 significantly decreased the rate of drug release from the nanospheres. These biocompatible nanospheres achieved sustained drug release for more than four months. MTT assay on human chondrosarcoma SW 1353 cells confirmed the biocompatibility of the nanospheres.

Fig. 2 TEM image of a cluster of prepared PVA nanoparticles loaded by Betamethasone Acetate and undergo 2 freeze-thaw cycles. (Bonakdar S.; et al. 2009)

References

Bonakdar S, et al. Effect of freezing and thawing process on betamethasone acetate release from polyvinyl alcohol nanospheres. Solid State Phenomena, 2009, 151: 159-165.

How does Betamethasone Acetate differ from Betamethasone Sodium Phosphate?

Betamethasone Acetate has lower water solubility, providing a prolonged depot effect valuable for studying extended-release glucocorticoid pharmacokinetics.

What storage conditions are required?

Should be stored at 2-8℃ in a tightly sealed container, protected from light and moisture.

What purity grade is available?

Supplied as a high-purity grade suitable for R&D and pharmaceutical manufacturing.

Can packaging be customized?

Packaging formats and order quantities are customizable upon request for R&D and production needs.