Altretamine

Inquiry

Cat Number

API0232301

CAS Number

645-05-6

For research use only. We do not supply to patients.

For pharmaceutical-grade products or other inquiries, please contact our experts.

Product Detail Description Customer Q&A

CAS Number

645-05-6

EINECS

211-428-4

Storage

Store at room temperature

Synonyms

Hexalen; Hexastat; Hemel; Altretamina; Melamine, hexamethyl-; Altretaminum

Molecular Formula

C9H18N6

Molecular Weight

210.28

Smiles

CN(C)C1=NC(=NC(=N1)N(C)C)N(C)C

Appearance

White to off-white solid powder

Melting Point

171-175°C

Boiling Point

339.4±25.0°C at 760 mmHg

Relative Density

1.1±0.1

General Description

Altretamine is a synthetic triazine derivative, a cytostatic agent with a hexamethylmelamine structure, belonging to the class of alkylating agents. Its chemical structure is 2,4,6-tris(dimethylamino)-1,3,5-triazine. Altretamine is a white to off-white crystalline powder, practically insoluble in water but soluble in organic solvents. It is a prodrug that requires activation to exert its cytotoxic effects.

Mechanism of Action

Altretamine is metabolized in the liver to formaldehyde, which acts as the active alkylating agent. Formaldehyde forms DNA cross-links, interfering with DNA replication and transcription, and leading to cell death. The drug is cell cycle-specific, affecting cells in the G2 and M phases. It also inhibits the synthesis of nucleic acids.

Application

Altretamine is indicated for the treatment of advanced ovarian cancer, particularly in patients who have failed or are resistant to other chemotherapeutic agents. It is used as a single agent or in combination with other drugs. The drug is effective in reducing tumor size and improving survival, but it is associated with significant side effects, including nausea and neurotoxicity.

Does Altretamine require protection from light during long-term storage?

Yes, it is photosensitive. UV exposure can cause photodegradation and discoloration of the triazine ring. Store in light-resistant containers, preferably amber glass.