Azathioprine Sodium

Inquiry

Cat Number

API55774339

CAS Number

55774-33-9

If you have any other questions, please contact our experts.

Product Detail Description Scientific Support Customer Q&A

CAS Number

55774-33-9

Storage

2-8℃

Synonyms

1H-Purine, 6-((1-methyl-4-nitro-1H-imidazol-5-yl)thio)-, sodium salt

Molecular Formula

C9H6N7NaO2S

Molecular Weight

299.25

Smiles

CN1C=NC(=C1SC2=NC=NC3=C2N=C[N-]3)[N+](=O)[O-].[Na+]

Appearance

Solid

General Description

Azathioprine Sodium is an immunosuppressive antimetabolite that functions as a prodrug of 6-mercaptopurine (6-MP). Administered in its sodium salt form to improve solubility, it is widely used in both organ transplantation and the treatment of autoimmune diseases. As an imidazoline derivative of 6-mercaptopurine, it interferes with purine nucleotide synthesis and lymphocyte proliferation.

Mechanism of Action

Azathioprine Sodium is converted to 6-mercaptopurine (6-MP) non-enzymatically in tissues, and 6-MP subsequently undergoes metabolic activation through hypoxanthine-guanine phosphoribosyltransferase (HGPRT) to active thiopurine nucleotides (TGNs). These nucleotides are incorporated into DNA and RNA during cell replication, causing DNA damage in rapidly dividing lymphocytes and inhibiting lymphocyte proliferation and function.

Application

Azathioprine Sodium is used as an immunosuppressive agent in organ transplantation (renal, hepatic, cardiac) for the prevention of allograft rejection, and in the management of autoimmune conditions including systemic lupus erythematosus (SLE), rheumatoid arthritis, Crohn's disease, and ulcerative colitis.

Azathioprine (AZA), an immunomodulator used in autoimmune disorders and transplantation, has active metabolites 6-mercaptopurine and 6-thioguanine. Recent applications include treating systemic lupus erythematosus, pemphigus vulgaris, and psoriasis. Pharmacogenomic testing of TPMT and NUDT15 genotypes minimizes myelosuppression risk. Nanotechnology-based formulations using biocompatible polymers improve efficacy and reduce systemic toxicity. These advancements enable precision medicine and expand AZA's clinical utility.

References

Rathi G, et al. Contemporary and prospective use of azathioprine (AZA) in viral, rheumatic, and dermatological disorders: a review of pharmacogenomic and nanotechnology applications. Naunyn-Schmiedeberg's Archives of Pharmacology, 2025, 398(4): 3183-3197.

What is the recommended storage condition for Azathioprine Sodium?

It should be stored at 2-8°C in a well-sealed container, protected from moisture and direct light, to maintain its chemical integrity throughout the shelf life.

Is a Certificate of Analysis (COA) available for Azathioprine Sodium?

Yes, a fully verified COA is issued for every batch and can be shared electronically. Additional documentation such as MSDS or impurity profiles may be requested separately.

What quantities of Azathioprine Sodium are available for order?

We accommodate orders of varying scale, from small research quantities through bulk commercial supply. Contact our sales team to discuss pack sizes and volume pricing.

Is Azathioprine Sodium available in oncology-grade specification?

Yes, it is supplied as an oncology-grade API with controlled impurity profiles and full analytical documentation to support formulation development.