Potassium Aminosalicylate

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Cat Number

API133095

CAS Number

133-09-5

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Product Detail Description Customer Q&A

CAS Number

133-09-5

EINECS

205-090-7

Synonyms

potassium 4-aminosalicylate;4-Aminosalicylic acid potassium

Molecular Formula

C7H6KNO3

Molecular Weight

191.23

Smiles

C1=CC(=C(C=C1N)O)C(=O)[O-].[K+]

General Description

Potassium Aminosalicylate is the potassium salt of 4-aminosalicylic acid (para-aminosalicylic acid, PAS), an antitubercular compound structurally related to para-aminobenzoic acid (PABA). The potassium salt form provides improved water solubility compared to the free acid.

Mechanism of Action

4-Aminosalicylic acid acts as a competitive inhibitor of dihydropteroate synthase in Mycobacterium tuberculosis by substituting for para-aminobenzoic acid (PABA) in the folate biosynthesis pathway, producing non-functional analogs of dihydrofolate that inhibit bacterial growth.

Application

Indicated for the treatment of tuberculosis as a second-line antitubercular agent. Potassium Aminosalicylate inhibits mycobacterial folate biosynthesis by competing with PABA at dihydropteroate synthase, disrupting essential folate-dependent metabolic pathways in Mycobacterium tuberculosis.

How does Potassium Aminosalicylate differ from isoniazid in mechanism?

Potassium Aminosalicylate inhibits folate biosynthesis by competing with PABA, whereas isoniazid inhibits mycolic acid biosynthesis, making them mechanistically complementary for combination therapy.