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Cat Number: API110429362

N-methyl Paroxetine

CAS Number

110429-36-2

Description

N-methyl Paroxetine is a derivative of the selective serotonin reuptake inhibitor (SSRI) antidepressant paroxetine that inhibits [3H]paroxetine binding to rat cortical membranes (Ki = 4.3 nM). It inhibits serotonin uptake in rat brain synaptosomes with an IC50 value of 22 nM. N-methyl Paroxetine has been used as a precursor in the synthesis of paroxetine and is a potential impurity in commercial preparations of paroxetine.

Molecular Formula

C20H22FNO3

Molecular Weight

343.39

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

Ethanol: 20 mg/mLDMF:PBS (pH 7) (1:10): 0.09 mg/mLDMSO: 20 mg/mLDMF: 33 mg/mL

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