Cefpiramide Sodium

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Cat Number

API74849937

CAS Number

74849-93-7

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Product Detail Description Advanced Innovations Customer Q&A

CAS Number

74849-93-7

EINECS

1592732-453-0

Storage

2-8℃

Synonyms

Sodium(6R,7R)-7-[[(2R)-2-(4-hydroxyphenyl)-2-[(6-methyl-4-oxo-1H-pyridine-3-carbonyl)amino]acetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;5-Thia-1Chemicalbook-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[[[(4-hydroxy-6-methyl-3-pyridinyl)carbonyl]amino](4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,monosodiumsalt,[6R-[6α,7β(R*)]]-

Molecular Formula

C25H23N8NaO7S2

Molecular Weight

634.6

Smiles

CC1=CC(=O)C(=CN1)C(=O)N[C@H](C2=CC=C(C=C2)O)C(=O)N[C@H]3[C@@H]4N(C3=O)C(=C(CS4)CSC5=NN=NN5C)C(=O)[O-].[Na+]

Appearance

White to off-white solid

General Description

Cefpiramide Sodium is a third-generation cephalosporin distinguished by an exceptionally long elimination half-life and dual hepatobiliary and renal excretion pathways, supporting once-daily dosing.

Mechanism of Action

Cefpiramide binds to penicillin-binding proteins in the bacterial cell wall, inhibiting transpeptidation of peptidoglycan cross-links. This weakens the cell wall and activates autolytic enzymes, resulting in bactericidal lysis.

Application

Used in the treatment of serious bacterial infections. Cefpiramide Sodium is indicated for respiratory tract infections, urinary tract infections, biliary tract infections, peritonitis, and septicemia caused by susceptible organisms.

Cefpiramide sodium-loaded liposomes were prepared by reverse phase evaporation method to improve the pharmacokinetics and tissue distribution of the antibiotic. In mice receiving a single intravenous injection of 152 mg/kg of either liposomal cefpiramide or cefpiramide solution, the liposomal formulation showed 2.8-fold higher bioavailability and 4.5-fold longer mean residence time compared to the solution. The targeting efficiency ratio of lung to other tissues was significantly elevated for liposomal cefpiramide, with an intake rate of 2.97 for the lung being the highest among tested tissues. The liposomes demonstrated a promising sustained-release and drug-targeting system for cefpiramide sodium.

Fig. 2 Transmission electron photomicrograms of cefpiramide sodium-loaded liposomes. (Sun Q.; et al. 2011)

References

Sun Q, et al. Tissue distribution and pulmonary targeting studies of cefpiramide sodium-loaded liposomes. Journal of Drug Targeting, 2011, 19(1): 49-55.

What pharmacokinetic advantage does Cefpiramide Sodium offer?

Cefpiramide features an exceptionally long half-life and dual biliary-renal excretion, enabling once-daily dosing and effective coverage for biliary tract infections.

What storage conditions are required?

Store at room temperature in a tightly sealed container, protected from light and moisture.

What purity grade is available?

It is supplied as a high-purity grade suitable for R&D and pharmaceutical manufacturing.

Can packaging and order quantities be customized?

Yes, both packaging formats and order quantities can be tailored to meet specific R&D and production needs.