Acrivastine

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Cat Number

API0232173

CAS Number

87848-99-5

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Product Detail Description Customer Q&A

CAS Number

87848-99-5

EINECS

618-080-6

Storage

Store at room temperature

Synonyms

Semprex; Acrivastina; BW-825C; Acrivastinum; DTXSID6022555

Molecular Formula

C22H24N2O2

Molecular Weight

348.4

Smiles

CC1=CC=C(C=C1)/C(=C\\CN2CCCC2)/C3=CC=CC(=N3)/C=C/C(=O)O

Appearance

White to pale cream crystalline powder

Melting Point

222°C (dec.)

Boiling Point

555.1±50.0°C (Predicted)

Relative Density

1.170±0.06 (Predicted)

General Description

Acrivastine is a second-generation, short-acting histamine H1 receptor antagonist belonging to the propylamine class, structurally related to triprolidine. Its structure features a pyridine ring, a propenyl group, and a carboxylic acid moiety, which confers zwitterionic properties.

Mechanism of Action

Acrivastine acts as a selective, competitive antagonist at peripheral H1 receptors, blocking histamine-induced vasodilation, increased vascular permeability, and sensory nerve stimulation. Its carboxylic acid group limits penetration across the blood-brain barrier, significantly reducing central nervous system effects. The drug has a rapid onset but a relatively short duration of action, requiring more frequent dosing compared to other second-generation antihistamines.

Application

Acrivastine is indicated for the symptomatic relief of seasonal allergic rhinitis and chronic idiopathic urticaria, effectively reducing sneezing, rhinorrhea, and pruritus. Its fast onset makes it suitable for on-demand use. The drug is approved in combination with pseudoephedrine and is generally well-tolerated, with drowsiness occurring at a slightly higher rate than with cetirizine or loratadine.

Does Acrivastine require protection from light during long-term storage?

Yes, it is photosensitive. UV exposure can cause photodegradation of the acrylic acid side chain. Store in light-resistant containers, preferably amber glass.

What is the recommended storage temperature for Acrivastine?

Store at controlled room temperature (15-25°C). Avoid excessive heat above 30°C, which can accelerate oxidation and degradation.

Is Acrivastine hygroscopic, and how is this managed?

It is slightly hygroscopic. Under high humidity (>70% RH), it may absorb moisture and clump. Storage in tightly sealed containers with desiccant is recommended.