Methdilazine Hydrochloride

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Cat Number

API1229352

CAS Number

1229-35-2

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Product Detail Description Customer Q&A

CAS Number

1229-35-2

Storage

Room temperature

Synonyms

10-((1-methyl-3-pyrrolidinyl)methyl)-phenothiazinhydrochloride

Molecular Formula

C18H21ClN2S

Molecular Weight

332.9

Smiles

CN1CCC(C1)CN2C3=CC=CC=C3SC4=CC=CC=C42.Cl

Appearance

Off-white solid

Melting Point

187.5-189℃

General Description

Methdilazine Hydrochloride is the hydrochloride salt of methdilazine, a phenothiazine-derived antihistamine with antipruritic properties. It belongs to the piperidyl phenothiazine subclass, featuring a methyl-substituted piperidyl group at the N-10 position of the phenothiazine ring system.

Mechanism of Action

Methdilazine Hydrochloride acts as a competitive antagonist at peripheral and central histamine H1 receptors, blocking histamine-mediated vasodilation, increased vascular permeability, and pruritus. It also exhibits some anticholinergic activity at muscarinic receptors.

Application

Indicated for the treatment of allergic conditions and pruritus. Methdilazine Hydrochloride is a phenothiazine-derived antihistamine with H1 receptor antagonism and antipruritic properties, belonging to the piperidyl phenothiazine subclass with distinct receptor selectivity from other phenothiazine antihistamines.

What distinguishes Methdilazine Hydrochloride from other phenothiazine antihistamines?

Methdilazine Hydrochloride belongs to the piperidyl subclass, whereas promethazine belongs to the propylamine subclass, resulting in different receptor selectivity profiles and CNS penetration characteristics.