Tripelennamine Hydrochloride

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Cat Number

API154698

CAS Number

154-69-8

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Product Detail Description Customer Q&A

CAS Number

154-69-8

EINECS

205-833-5

Storage

Room temperature

Synonyms

2-(benzyl(2-(dimethylamino)ethyl)amino)-pyridinmonohydrochloride

Molecular Formula

C16H22ClN3

Molecular Weight

291.82

Smiles

CN(C)CCN(CC1=CC=CC=C1)C2=CC=CC=N2.Cl

Appearance

White to off-white solid

Melting Point

192-193℃

Relative Density

1.2

General Description

Tripelennamine Hydrochloride is a first-generation antihistamine (H1 receptor antagonist) of the ethylenediamine class, notable for its relatively rapid onset and moderate duration of action. The hydrochloride salt provides enhanced aqueous solubility and is suitable for both oral and topical (dermal) administration. It has been used clinically since the mid-20th century for allergy management.

Mechanism of Action

Tripelennamine Hydrochloride competitively antagonizes histamine H1 receptors on smooth muscle cells, endothelial cells, and sensory nerve endings, blocking histamine-mediated vasodilation, increased vascular permeability, edema formation, and pruritus. Its ethylenediamine structure confers a degree of anticholinergic activity that contributes to drying effects on respiratory secretions.

Application

Tripelennamine Hydrochloride is indicated for the symptomatic treatment of allergic conditions including allergic rhinitis, hay fever, urticaria, and allergic skin reactions.

What is the recommended storage condition for Tripelennamine Hydrochloride?

It should be stored at controlled room temperature in a well-sealed container, protected from moisture and direct light, to maintain its chemical integrity throughout the shelf life.

Is a Certificate of Analysis (COA) available for Tripelennamine Hydrochloride?

Yes, a fully verified COA is issued for every batch and can be shared electronically. Additional documentation such as MSDS or impurity profiles may be requested separately.

What quantities of Tripelennamine Hydrochloride are available for order?

We accommodate orders of varying scale, from small research quantities through bulk commercial supply. Contact our sales team to discuss pack sizes and volume pricing.

Is Tripelennamine Hydrochloride compatible with both oral and topical formulations?

Compatibility with oral solid dosage forms and topical formulations is well documented in the literature. Formulation-grade material is available for both application types.