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Cat Number: API1616493447

Tucidinostat

CAS Number

1616493-44-7

Description

Tucidinostat (Chidamide) is an effective and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8/11 (IC50: 733/432 nM), and shows no effect on HDAC4/5/6/7/9.

Molecular Formula

C22H19FN4O2

Molecular Weight

390.41

Smiles

NC1CC(F)CCC1NC(=O)C1CCC(CNC(=O)\C=C\C2CCCNC2)CC1

Purity

0.9876

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Solubility Information

H2O: Insoluble10% DMSO+40% PEG300+5% Tween 80+45% Saline: 6 mg/mL (15.37 mM), In vivo: Suspension. Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.DMSO: 60 mg/mL (153.68 mM)Ethanol: 1 mg/mL

Relative Density

1.336 (Predicted)

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