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Trametinib

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Cat Number

API871700173

CAS Number

871700-17-3

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Product Detail

CAS Number

871700-17-3

Storage

Powder: -20℃ for 3 years. In solvent: -80℃ for 1 year.

Description

Trametinib (GSK1120212) is a MEK inhibitor that inhibits MEK1 and MEK2 (IC50=0.7/0.9 nM) with ATP non-competitive and oral activity. Trametinib activates autophagy and induces apoptosis.

Molecular Formula

C26H23FIN5O4

Molecular Weight

615.39

Smiles

N(C1=C2C(N(C(=O)N(C2=O)C3CC3)C4=CC(NC(C)=O)=CC=C4)=C(C)C(=O)N1C)C5=C(F)C=C(I)C=C5

Relative Density

1.743

Purity

0.9988

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