Fluprednisolone

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Cat Number

API53349

CAS Number

53-34-9

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Product Detail Description Customer Q&A

CAS Number

53-34-9

EINECS

200-170-8

Storage

2-8℃

Synonyms

6-a-Fluorprednisolone

Molecular Formula

C21H27FO5

Molecular Weight

378.4

Smiles

C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)CO)O)C[C@@H](C4=CC(=O)C=C[C@]34C)F)O

Melting Point

208-213℃

Relative Density

1.1

General Description

Fluprednisolone is a synthetic fluorinated intermediate-acting glucocorticoid of the corticosteroid class. Fluorination at the 6-alpha position enhances anti-inflammatory potency while reducing mineralocorticoid activity.

Mechanism of Action

Fluprednisolone binds cytosolic glucocorticoid receptors and the complex translocates to the nucleus, inducing anti-inflammatory gene products while suppressing pro-inflammatory cytokines, prostaglandins, and leukotrienes.

Application

Used in the treatment of inflammatory and allergic disorders. Fluprednisolone is indicated for rheumatoid arthritis, allergic conditions, dermatological disorders, and adrenal insufficiency replacement therapy.

What is the significance of 6-alpha fluorination?

6-alpha fluorination enhances glucocorticoid receptor affinity and increases metabolic stability, providing approximately four times the anti-inflammatory potency of hydrocortisone.