Tiludronate Disodium

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Cat Number

API149845078

CAS Number

149845-07-8

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Product Detail Description Customer Q&A

CAS Number

149845-07-8

Synonyms

Tiludronic acid disodium salt

Molecular Formula

C7H7ClNa2O6P2S

Molecular Weight

362.57

Smiles

C1=CC(=CC=C1SC(P(=O)(O)[O-])P(=O)(O)[O-])Cl.[Na+].[Na+]

General Description

Tiludronate Disodium is a bisphosphonate inhibitor of bone resorption used for the treatment of Paget's disease of bone (osteitis deformans) and hypercalcemia of malignancy. Its molecular structure features a chloro-thienyl side chain attached to the bisphosphonate backbone, which confers moderate potency and a distinct binding profile to bone mineral compared to other bisphosphonates.

Mechanism of Action

Tiludronate Disodium localizes to bone hydroxyapatite mineral surfaces where it is internalized by osteoclasts during bone resorption. Once inside the osteoclast, it inhibits the enzyme farnesyl pyrophosphate synthase (FPPS) in the mevalonate pathway, preventing the synthesis of isoprenoid lipids required for post-translational modification (prenylation) of small GTPase signaling proteins essential for osteoclast ruffled border formation, cytoskeletal organization, and survival. This causes osteoclast apoptosis and reduces bone resorption.

Application

Tiludronate Disodium is indicated for the treatment of Paget's disease of bone, where it normalizes elevated bone turnover markers and reduces bone pain, deformity, and fracture risk.

What is the recommended storage condition for Tiludronate Disodium?

It should be stored at controlled room temperature in a well-sealed container, protected from moisture and direct light, to maintain its chemical integrity throughout the shelf life.

Is a Certificate of Analysis (COA) available for Tiludronate Disodium?

Yes, a fully verified COA is issued for every batch and can be shared electronically. Additional documentation such as MSDS or impurity profiles may be requested separately.

What quantities of Tiludronate Disodium are available for order?

We accommodate orders of varying scale, from small research quantities through bulk commercial supply. Contact our sales team to discuss pack sizes and volume pricing.

Is Tiludronate Disodium compatible with standard pharmaceutical formulation processes?

Pharmaceutical-grade material suitable for standard formulation processes is available. Technical data sheets and compatibility information can be provided upon request.