Isoetharine Mesylate

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Cat Number

API0232112

CAS Number

7279-75-6

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Product Detail Description Customer Q&A

CAS Number

7279-75-6

EINECS

230-695-8

Storage

Store at 2-8°C

Synonyms

Isoetarine mesilate; Bronkometer; DTXSID2045571; isoetharine mesilate; NSC-759286; DTXCID0025571; Bronchilator

Molecular Formula

C14H25NO6S

Molecular Weight

335.42

Smiles

CCC(C(C1=CC(=C(C=C1)O)O)O)NC(C)C.CS(=O)(=O)O

Appearance

White to off-white powder

Melting Point

162-168°C

Boiling Point

429.3°C at 760 mmHg

General Description

Isoetharine mesylate is a selective beta-2 adrenergic agonist belonging to the catecholamine class, with a structure similar to isoproterenol but with an ethyl substitution on the α-carbon. The mesylate salt improves aqueous stability. The molecule has two hydroxyl groups on the benzene ring (catechol moiety) and a secondary amine group. It is rapidly metabolized by catechol-O-methyltransferase (COMT), limiting its duration of action.

Mechanism of Action

Isoetharine binds to and activates beta-2 adrenergic receptors on bronchial smooth muscle cells, stimulating adenylate cyclase and increasing intracellular cyclic AMP. This leads to relaxation of bronchial smooth muscle, bronchodilation, and inhibition of mast cell mediator release. The drug has minimal beta-1 activity at therapeutic doses, thus causing less cardiac stimulation than isoproterenol. The catechol structure makes it susceptible to rapid inactivation.

Application

Isoetharine was indicated as a bronchodilator for the treatment of asthma, chronic bronchitis, and emphysema, particularly in acute bronchospasm. It was available as an inhalation aerosol and solution for nebulization.

Does Isoetharine Mesylate require protection from light and oxygen during storage?

Yes, it is highly sensitive to both. Light and air cause oxidation and discoloration (pink to brown). Store in airtight, light-resistant containers under inert gas.

What is the recommended storage temperature for Isoetharine Mesylate?

Store at 2-8°C (refrigerated). At room temperature, rapid oxidation and degradation of the catechol moiety occur, leading to loss of potency.

Is Isoetharine Mesylate stable in solution for nebulization?

Solutions are very unstable; they should be prepared fresh and protected from light.

How is the impurity isoetharine sulfonate (an oxidative degradation product) monitored?

This degradation product is quantified using a stability-indicating HPLC method, ensuring it remains below pharmacopoeial limits.