Sulfadiazine Sodium

In a rat study, second‑degree burns covering less than 10% body surface area were left untreated (control) or treated daily with povidone‑iodine, saline, or silver sulfadiazine for 21 days. Histological evaluation of inflammatory cells, vascularization, fibroblast proliferation, collagen formation, and epithelialization revealed no statistically significant differences between any treatment group and the control. The authors conclude that, under these experimental conditions, none of the three common burn dressings showed superiority over no treatment. They call for further studies using deeper or larger burn wounds to better assess these agents’ clinical utility.

Fig. 1 Hematoxylin and eosin staining. (Yüksel EB, et al., 2014)

New sulfadiazine‑chitosan conjugates were used to form polyelectrolyte complexes with sodium hyaluronate. The complexes were characterized by FTIR, SEM, and near‑infrared chemical imaging. They demonstrated antimicrobial activity against E. coli, Listeria monocytogenes, and Salmonella typhymurium, with complexes containing sulfadiazine‑modified chitosan being more active than those with unmodified chitosan. These PECs have potential for burn wound treatment.

Fig. 2 Swelling behavior of PEC (polyelectrolyte complexe) sponges in PBS (phosphate buffered saline) pH 7.4 at 37 °C. (Dumitriu RP, et al., 2015)