Solifenacin Succinate

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Cat Number

API242478382

CAS Number

242478-38-2

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Product Detail Description Customer Q&A

CAS Number

242478-38-2

EINECS

620-505-5

Storage

2-8℃

Synonyms

1-azabicyclo[2.2.2]octan-8-yl (1s)-1-phenyl-3,4-dihydro-1h-isoquinoline-2-carboxylate butanedioic acid

Molecular Formula

C27H32N2O6

Molecular Weight

480.6

Smiles

C1CN2CCC1[C@H](C2)OC(=O)N3CCC4=CC=CC=C4[C@@H]3C5=CC=CC=C5.C(CC(=O)O)C(=O)O

Appearance

White to off-white solid

Melting Point

145℃

General Description

Solifenacin Succinate is a competitive muscarinic receptor antagonist with high selectivity for M3 receptors over M2 receptors. This selectivity provides effective bladder relaxation while minimizing cardiac and CNS effects.

Mechanism of Action

Solifenacin selectively blocks M3 muscarinic receptors on bladder detrusor smooth muscle, inhibiting acetylcholine-mediated contraction during the filling phase, increasing bladder capacity and reducing urgency and frequency.

Application

Used in the treatment of overactive bladder. Solifenacin Succinate is indicated for urge urinary incontinence, urinary urgency, and urinary frequency associated with overactive bladder syndrome.

What advantage does M3 selectivity provide in overactive bladder treatment?

M3 selectivity provides effective bladder relaxation while minimizing M2-mediated cardiac effects and CNS side effects common with non-selective anticholinergics.